quantitative mouse behavior and optogenetics

The mammalian brains have millions to billions of neurons with trillions of connections. This complicated network supports numerous behaviors including high level cognitive functions such as working memory, decision-making.
Understanding how the neural circuits generate behaviors is a fundamental challenge in modern neuroscience. To understand how working memory is generated, maintained and discharged in the mammalian brain, we integrate optogenetics, multi-channel recording, 2-photon imaging and quantitative behavior to probe neural dynamics underlying working memory.